Human MUC4 activation kit by CRISPRa

SKU GA103035

MUC4 CRISPRa kit - CRISPR gene activation of human mucin 4, cell surface associated

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MUC4
• Locus ID: 4585
• Components:

  GA103035G1, MUC4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103035G2, MUC4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103035G3, MUC4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001322468, NM_004532, NM_018406, NM_138297, NM_138298, NM_138299
• UniProt ID: Q99102
• Synonyms: ASGP; HSA276359; MUC-4
• Summary: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]