Human MRE11 activation kit by CRISPRa

SKU GA102971

MRE11 CRISPRa kit - CRISPR gene activation of human MRE11 homolog, double strand break repair nuclease

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MRE11
• Locus ID: 4361
• Components:

  GA102971G1, MRE11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102971G2, MRE11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102971G3, MRE11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_005590, NM_005591, NM_001330347
• UniProt ID: P49959
• Synonyms: ATLD; HNGS1; MRE11; MRE11B
• Summary: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]