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Human SMAD1 activation kit by CRISPRa

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SKU
GA102774
SMAD1 CRISPRa kit - CRISPR gene activation of human SMAD family member 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC200299 SMAD1 (Myc-DDK-tagged)-Human SMAD family member 1 (SMAD1), transcript variant 2
10 ug
$457.00

Other products for "SMAD1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SMAD1
Locus ID 4086
Components

GA102774G1, SMAD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102774G2, SMAD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102774G3, SMAD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001003688, NM_005900, NM_001354811, NM_001354812, NM_001354813, NM_001354814, NM_001354816, NM_001354817
UniProt ID Q15797
Synonyms BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1
Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN400299 SMAD1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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