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Human KPNA2 activation kit by CRISPRa

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SKU
GA102602
KPNA2 CRISPRa kit - CRISPR gene activation of human karyopherin subunit alpha 2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA319672 Rabbit Polyclonal KPNA2 Antibody
100 ug
$640.00
RC208803 KPNA2 (Myc-DDK-tagged)-Human karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)
10 ug
$492.00

Other products for "KPNA2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol KPNA2
Locus ID 3838
Components

GA102602G1, KPNA2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102602G2, KPNA2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102602G3, KPNA2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001320611, NM_002266
UniProt ID P52292
Synonyms IPOA1; QIP2; RCH1; SRP1-alpha; SRP1alpha
Summary The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. provided by RefSeq, Feb 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN408803 KPNA2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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