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Human KIR2DS3 activation kit by CRISPRa

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SKU
GA102578
KIR2DS3 CRISPRa kit - CRISPR gene activation of human killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC213617 KIR2DS3 (Myc-DDK-tagged)-Human killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3)
10 ug
$300.00

Other products for "KIR2DS3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol KIR2DS3
Locus ID 3808
Components

GA102578G1, KIR2DS3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102578G2, KIR2DS3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102578G3, KIR2DS3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_012313
UniProt ID Q14952
Synonyms NKAT7
Summary Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN413617 KIR2DS3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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