Human Kv2.1 (KCNB1) activation kit by CRISPRa

SKU GA102521

KCNB1 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily B member 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: KCNB1
• Locus ID: 3745
• Components:

  GA102521G1, Kv2.1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102521G2, Kv2.1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102521G3, Kv2.1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004975
• UniProt ID: Q14721
• Synonyms: DRK1; EIEE26; h-DRK1; KV2.1
• Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]