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Human JAK1 activation kit by CRISPRa

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SKU
GA102502
JAK1 CRISPRa kit - CRISPR gene activation of human Janus kinase 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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Other products for "JAK1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol JAK1
Locus ID 3716
Components

GA102502G1, JAK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102502G2, JAK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102502G3, JAK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001320923, NM_001321852, NM_001321853, NM_001321854, NM_001321855, NM_001321856, NM_001321857, NM_002227
UniProt ID P23458
Synonyms JAK1A; JAK1B; JTK3
Summary This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2020
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Documents
Resources
Other Versions
SKU Description Size Price
KN213878 JAK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213878BN JAK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213878LP JAK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213878RB JAK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN413878 JAK1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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