Human CD11b (ITGAM) activation kit by CRISPRa

SKU GA102474

ITGAM CRISPRa kit - CRISPR gene activation of human integrin subunit alpha M

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ITGAM
• Locus ID: 3684
• Components:

  GA102474G1, CD11b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102474G2, CD11b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102474G3, CD11b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000632, NM_001145808
• UniProt ID: P11215
• Synonyms: CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6
• Summary: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]