Human CD49b (ITGA2) activation kit by CRISPRa

SKU GA102464

ITGA2 CRISPRa kit - CRISPR gene activation of human integrin subunit alpha 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ITGA2
• Locus ID: 3673
• Components:

  GA102464G1, CD49b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102464G2, CD49b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102464G3, CD49b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002203, NR_073103, NR_073104, NR_073105, NR_073106, NR_073107
• UniProt ID: P17301
• Synonyms: BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2
• Summary: This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]