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Human SHIP (INPP5D) activation kit by CRISPRa

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SKU
GA102437
INPP5D CRISPRa kit - CRISPR gene activation of human inositol polyphosphate-5-phosphatase D
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA365014 INPP5D rabbit polyclonal antibody
100 ul
$310.00
RC212176 INPP5D (Myc-DDK-tagged)-Human inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 2
10 ug
$1,034.00

Other products for "INPP5D"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol INPP5D
Locus ID 3635
Components

GA102437G1, SHIP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102437G2, SHIP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102437G3, SHIP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001017915, NM_005541
UniProt ID Q92835
Synonyms hp51CN; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145
Summary This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. provided by RefSeq, Jul 2020
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Documents
Resources
Other Versions
SKU Description Size Price
KN412176 INPP5D - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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