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Human IL17 (IL17A) activation kit by CRISPRa

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SKU
GA102412
IL17A CRISPRa kit - CRISPR gene activation of human interleukin 17A
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA700015 lL-17 biotinylated mouse monoclonal detection antibody, validated for ELISA and Luminex assays
50 ug
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RC218057 IL17A (Myc-DDK-tagged)-Human interleukin 17A (IL17A)
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Other products for "IL17A"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol IL17A
Locus ID 3605
Components

GA102412G1, IL17 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102412G2, IL17 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102412G3, IL17 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_002190
UniProt ID Q16552
Synonyms CTLA8; IL-17; IL-17A; IL17
Summary This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. provided by RefSeq, Sep 2020
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Documents
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Other Versions
SKU Description Size Price
KN418057 IL17A - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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