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Human CXCR2 activation kit by CRISPRa

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SKU
GA102394
CXCR2 CRISPRa kit - CRISPR gene activation of human C-X-C motif chemokine receptor 2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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Other products for "CXCR2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CXCR2
Locus ID 3579
Components

GA102394G1, CXCR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102394G2, CXCR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102394G3, CXCR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001168298, NM_001557
UniProt ID P25025
Synonyms CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
Summary The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. provided by RefSeq, Nov 2009
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Documents
Resources
Other Versions
SKU Description Size Price
KN207794 CXCR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN207794BN CXCR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN207794LP CXCR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN207794RB CXCR2 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN407794 CXCR2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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