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Human IL4R activation kit by CRISPRa

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SKU
GA102383
IL4R CRISPRa kit - CRISPR gene activation of human interleukin 4 receptor
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC214464 IL4R (Myc-DDK-tagged)-Human interleukin 4 receptor (IL4R), transcript variant 1
10 ug
$727.00

Other products for "IL4R"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol IL4R
Locus ID 3566
Components

GA102383G1, IL4R gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102383G2, IL4R gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102383G3, IL4R gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000418, NM_001008699, NM_001257406, NM_001257407, NM_001257997
UniProt ID P24394
Synonyms CD124; IL-4RA; IL4RA
Summary This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. provided by RefSeq, Apr 2012
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Documents
Resources
Other Versions
SKU Description Size Price
KN414464 IL4R - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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