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Human Factor I (CFI) activation kit by CRISPRa

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SKU
GA102318
CFI CRISPRa kit - CRISPR gene activation of human complement factor I
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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$447.00
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Other products for "CFI"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CFI
Locus ID 3426
Components

GA102318G1, Factor I gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102318G2, Factor I gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102318G3, Factor I gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000204, NM_001318057, NM_001331035, N63668
UniProt ID P05156
Synonyms AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF
Summary This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. provided by RefSeq, Dec 2015
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Other Versions
SKU Description Size Price
KN416645 CFI - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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