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Human HSPA6 activation kit by CRISPRa

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SKU
GA102262
HSPA6 CRISPRa kit - CRISPR gene activation of human heat shock protein family A (Hsp70) member 6
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA501950 HSPA6 mouse monoclonal antibody, clone OTI1D12 (formerly 1D12) 100 ul
$447.00
RC207795 HSPA6 (Myc-DDK-tagged)-Human heat shock 70kDa protein 6 (HSP70B') (HSPA6)
10 ug
$897.00

Other products for "HSPA6"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol HSPA6
Locus ID 3310
Components

GA102262G1, HSPA6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102262G2, HSPA6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102262G3, HSPA6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_002155
UniProt ID P17066
Synonyms heat shock 70kDa protein 6 (HSP70B'); heat shock 70kD protein 6 (HSP70B')
Summary Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN407795 HSPA6 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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