Human PRMT2 activation kit by CRISPRa

SKU GA102239

PRMT2 CRISPRa kit - CRISPR gene activation of human protein arginine methyltransferase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PRMT2
• Locus ID: 3275
• Components:

  GA102239G1, PRMT2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102239G2, PRMT2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102239G3, PRMT2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001242864, NM_001242865, NM_001242866, NM_001286676, NM_001286677, NM_001286678, NM_001535, NM_206962
• UniProt ID: P55345
• Synonyms: HRMT1L1
• Summary: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.[UniProtKB/Swiss-Prot Function]