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Human Haptoglobin (HP) activation kit by CRISPRa

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SKU
GA102222
HP CRISPRa kit - CRISPR gene activation of human haptoglobin
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA501699 Anti-HP mouse monoclonal antibody, clone OTI4H5 (formerly 4H5) 100 ul
$447.00
RC223612 HP (Myc-DDK-tagged)-Human haptoglobin (HP), transcript variant 1
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Other products for "HP"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol HP
Locus ID 3240
Components

GA102222G1, Haptoglobin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102222G2, Haptoglobin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102222G3, Haptoglobin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001126102, NM_001318138, NM_005143
UniProt ID P00738
Synonyms BP; HP2ALPHA2; HPA1S
Summary This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Oct 2014
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Documents
Resources
Other Versions
SKU Description Size Price
KN423612 HP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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