Human HOXD10 activation kit by CRISPRa

SKU GA102218

HOXD10 CRISPRa kit - CRISPR gene activation of human homeobox D10

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: HOXD10
• Locus ID: 3236
• Components:

  GA102218G1, HOXD10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102218G2, HOXD10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102218G3, HOXD10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002148
• UniProt ID: P28358
• Synonyms: Hox-4.4; HOX4; HOX4D; HOX4E
• Summary: This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]