Human HOXB4 activation kit by CRISPRa

SKU GA102198

HOXB4 CRISPRa kit - CRISPR gene activation of human homeobox B4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: HOXB4
• Locus ID: 3214
• Components:

  GA102198G1, HOXB4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102198G2, HOXB4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102198G3, HOXB4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_024015
• UniProt ID: P17483
• Synonyms: HOX-2.6; HOX2; HOX2F
• Summary: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]