Human MR1 activation kit by CRISPRa

SKU GA102141

MR1 CRISPRa kit - CRISPR gene activation of human major histocompatibility complex, class I-related

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MR1
• Locus ID: 3140
• Components:

  GA102141G1, MR1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102141G2, MR1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102141G3, MR1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001194999, NM_001195000, NM_001195035, NM_001310213, NM_001531
• UniProt ID: Q95460
• Synonyms: HLALS
• Summary: MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]