Human GNA11 activation kit by CRISPRa

SKU GA101841

GNA11 CRISPRa kit - CRISPR gene activation of human G protein subunit alpha 11

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GNA11
• Locus ID: 2767
• Components:

  GA101841G1, GNA11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101841G2, GNA11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101841G3, GNA11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002067
• UniProt ID: P29992
• Synonyms: FBH; FBH2; FHH2; GNA-11; HHC2; HYPOC2
• Summary: The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]