Human GDF 9 (GDF9) activation kit by CRISPRa

SKU GA101776

GDF9 CRISPRa kit - CRISPR gene activation of human growth differentiation factor 9

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GDF9
• Locus ID: 2661
• Components:

  GA101776G1, GDF 9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101776G2, GDF 9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101776G3, GDF 9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001288824, NM_001288825, NM_001288826, NM_001288827, NM_001288828, NM_005260
• UniProt ID: O60383
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins. [provided by RefSeq, Jul 2016]