Human GBE1 activation kit by CRISPRa

SKU GA101752

GBE1 CRISPRa kit - CRISPR gene activation of human 1,4-alpha-glucan branching enzyme 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GBE1
• Locus ID: 2632
• Components:

  GA101752G1, GBE1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101752G2, GBE1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101752G3, GBE1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000158
• UniProt ID: Q04446
• Synonyms: APBD; GBE; GSD4
• Summary: The protein encoded by this gene is a glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain. Branching of the chains is essential to increase the solubility of the glycogen molecule and, consequently, in reducing the osmotic pressure within cells. Highest level of this enzyme are found in liver and muscle. Mutations in this gene are associated with glycogen storage disease IV (also known as Andersen's disease). [provided by RefSeq, Jul 2008]