Human GABRA2 activation kit by CRISPRa

SKU GA101698

GABRA2 CRISPRa kit - CRISPR gene activation of human gamma-aminobutyric acid type A receptor alpha2 subunit

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GABRA2
• Locus ID: 2555
• Components:

  GA101698G1, GABRA2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101698G2, GABRA2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101698G3, GABRA2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000807, NM_001114175, NM_001286827, NM_001330690
• UniProt ID: P47869
• Synonyms: FLJ97076
• Summary: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]