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Human FMO3 activation kit by CRISPRa

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SKU
GA101635
FMO3 CRISPRa kit - CRISPR gene activation of human flavin containing dimethylaniline monoxygenase 3
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA808310 FMO3 mouse monoclonal antibody, clone OTI3H1 (formerly 3H1) 100 ul
$447.00
RC206506 FMO3 (Myc-DDK-tagged)-Human flavin containing monooxygenase 3 (FMO3), transcript variant 1
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Other products for "FMO3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol FMO3
Locus ID 2328
Components

GA101635G1, FMO3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101635G2, FMO3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101635G3, FMO3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001002294, NM_001319173, NM_001319174, NM_006894
UniProt ID P31513
Synonyms dJ127D3.1; FMOII; TMAU
Summary Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.provided by RefSeq, Jan 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN406506 FMO3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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