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Human Prothrombin (F2) activation kit by CRISPRa

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SKU
GA101495
F2 CRISPRa kit - CRISPR gene activation of human coagulation factor II, thrombin
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA812513 F2 mouse monoclonal antibody,clone OTI5G10 100 ul
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RC208589 F2 (Myc-DDK-tagged)-Human coagulation factor II (thrombin) (F2)
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Other products for "F2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol F2
Locus ID 2147
Components

GA101495G1, Prothrombin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101495G2, Prothrombin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101495G3, Prothrombin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000506, NM_001311257
UniProt ID P00734
Synonyms PT; RPRGL2; THPH1
Summary This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. provided by RefSeq, May 2020
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Documents
Resources
Other Versions
SKU Description Size Price
KN408589 F2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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