Human MARK2 activation kit by CRISPRa

SKU GA101394

MARK2 CRISPRa kit - CRISPR gene activation of human microtubule affinity regulating kinase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MARK2
• Locus ID: 2011
• Components:

  GA101394G1, MARK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101394G2, MARK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101394G3, MARK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001039468, NM_001039469, NM_001163296, NM_001163297, NM_004954, NM_017490
• UniProt ID: Q7KZI7
• Synonyms: ELKL motif kinase 1; EMK1; MAP/microtubule affinity-regulating kinase 2; MGC99619; PAR-1; Par1b; protein-serine/threonine kinase; Ser/Thr protein kinase PAR-1B; serine/threonine kinase
• Summary: This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]