Human Desmoglein 2 (DSG2) activation kit by CRISPRa

SKU GA101280

DSG2 CRISPRa kit - CRISPR gene activation of human desmoglein 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: DSG2
• Locus ID: 1829
• Components:

  GA101280G1, Desmoglein 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101280G2, Desmoglein 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101280G3, Desmoglein 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001943
• UniProt ID: Q14126
• Synonyms: CDHF5; HDGC
• Summary: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]