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Human MRP2 (ABCC2) activation kit by CRISPRa

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SKU
GA100877
ABCC2 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily C member 2
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC218976 ABCC2 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ABCC2)
10 ug
$1,982.00

Other products for "ABCC2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ABCC2
Locus ID 1244
Components

GA100877G1, MRP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100877G2, MRP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100877G3, MRP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000392
UniProt ID Q92887
Synonyms ABC30; CMOAT; cMRP; DJS; MRP2
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN418976 ABCC2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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