Human AP2M1 activation kit by CRISPRa

SKU GA100836

AP2M1 CRISPRa kit - CRISPR gene activation of human adaptor related protein complex 2 subunit mu 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: AP2M1
• Locus ID: 1173
• Components:

  GA100836G1, AP2M1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100836G2, AP2M1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100836G3, AP2M1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001025205, NM_001311198, NM_004068
• UniProt ID: Q96CW1
• Synonyms: AP50; CLAPM1; mu2
• Summary: This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]