Human CD30 (TNFRSF8) activation kit by CRISPRa

SKU GA100665

TNFRSF8 CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 8

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TNFRSF8
• Locus ID: 943
• Components:

  GA100665G1, CD30 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100665G2, CD30 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100665G3, CD30 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001243, NM_001281430, NM_152942
• UniProt ID: P28908
• Synonyms: CD30; D1S166E; Ki-1
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]