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Human Caspase 1 (CASP1) activation kit by CRISPRa

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SKU
GA100587
CASP1 CRISPRa kit - CRISPR gene activation of human caspase 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC218364 CASP1 (Myc-DDK-tagged)-Human caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (CASP1), transcript variant alpha
10 ug
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Other products for "CASP1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CASP1
Locus ID 834
Components

GA100587G1, Caspase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100587G2, Caspase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100587G3, Caspase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001223, NM_001257118, NM_001257119, NM_033292, NM_033293, NM_033294, NM_033295
UniProt ID P29466
Synonyms ICE; IL1BC; P45
Summary This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. provided by RefSeq, Mar 2012
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Documents
Resources
Other Versions
SKU Description Size Price
KN409125 CASP1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis
Ey, Eyking, Klepak et al
J. Immunol. (2013) 190 (11), 5676-88 DOI: 10.4049/jimmunol.1201592
Cited by 56
AI Summary: OriGene’s caspase-1 protease assay kit with red fluorescence substrate was used to detect caspase-1 activation and pyroptosis in live cells, helping to demonstrate the role of commensally induced pyroptosis in colitis progression in this study.
Snippet: Samples were then minced into small pieces and further digested with collagenase II (1.5 mg/ml;Life Technologies) and dispase (1.0 mg ... of caspase-1 activation, live cells were stained with the caspase-1 protease assay kit with red fluorescence substrate (Origene) and Hoechst
Showing 1-1 of 1 papers.
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