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Human BARD1 activation kit by CRISPRa

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SKU
GA100399
BARD1 CRISPRa kit - CRISPR gene activation of human BRCA1 associated RING domain 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA313499 Rabbit polyclonal anti-BARD1 antibody
100 ul
$380.00
RC211511 BARD1 (Myc-DDK-tagged)-Human BRCA1 associated RING domain 1 (BARD1)
10 ug
$1,067.00

Other products for "BARD1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol BARD1
Locus ID 580
Components

GA100399G1, BARD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100399G2, BARD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100399G3, BARD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000465, NM_001282543, NM_001282545, NM_001282548, NM_001282549, NR_104212, NR_104215, NR_104216
UniProt ID Q99728
Synonyms BRCA1 associated RING domain 1; BRCA1-associated RING domain 1; BRCA1-associated RING domain gene 1
Summary This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Sep 2013
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Documents
Resources
Other Versions
SKU Description Size Price
KN411511 BARD1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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