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Human AUH activation kit by CRISPRa

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SKU
GA100379
AUH CRISPRa kit - CRISPR gene activation of human AU RNA binding methylglutaconyl-CoA hydratase
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC218117 AUH (Myc-DDK-tagged)-Human AU RNA binding protein/enoyl-CoA hydratase (AUH), nuclear gene encoding mitochondrial protein
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Other products for "AUH"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol AUH
Locus ID 549
Components

GA100379G1, AUH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100379G2, AUH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100379G3, AUH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001306190, NM_001698, NM_001351431, NM_001351432, NM_001351433
UniProt ID Q13825
Summary This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
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Documents
Resources
Other Versions
SKU Description Size Price
KN418117 AUH - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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