Human PHOX2A activation kit by CRISPRa

SKU GA100291

PHOX2A CRISPRa kit - CRISPR gene activation of human paired like homeobox 2A

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PHOX2A
• Locus ID: 401
• Components:

  GA100291G1, PHOX2A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100291G2, PHOX2A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100291G3, PHOX2A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_005169
• UniProt ID: O14813
• Synonyms: ARIX; CFEOM2; FEOM2; NCAM2; PMX2A
• Summary: The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008]