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Human FE65 (APBB1) activation kit by CRISPRa

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SKU
GA100223
APBB1 CRISPRa kit - CRISPR gene activation of human amyloid beta precursor protein binding family B member 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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RC202003 APBB1 (Myc-DDK-tagged)-Human amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 1
10 ug
$648.00

Other products for "APBB1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol APBB1
Locus ID 322
Components

GA100223G1, FE65 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA100223G2, FE65 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA100223G3, FE65 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001164, NM_001257319, NM_001257320, NM_001257321, NM_001257322, NM_001257323, NM_001257324, NM_001257325, NM_001257326, NM_145689, NR_047512
UniProt ID O00213
Synonyms FE65; MGC:9072; RIR
Summary The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. provided by RefSeq, Mar 2012
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Documents
Resources
Other Versions
SKU Description Size Price
KN402003 APBB1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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