Human ALAS2 activation kit by CRISPRa

SKU GA100147

ALAS2 CRISPRa kit - CRISPR gene activation of human 5'-aminolevulinate synthase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ALAS2
• Locus ID: 212
• Components:

  GA100147G1, ALAS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100147G2, ALAS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100147G3, ALAS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000032, NM_001037967, NM_001037968, NM_001037969
• UniProt ID: P22557
• Synonyms: ALAS-E; ALASE; ANH1; ASB; SIDBA1; XLDPP; XLEPP; XLSA
• Summary: The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]