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ASCL1 (NM_004316) Human Tagged ORF Clone Lentiviral Particle

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SKU
RC201123L1V
Lenti ORF particles, ASCL1 (Myc-DDK tagged) - Human achaete-scute complex homolog 1 (Drosophila) (ASCL1), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
DDK tGFP
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
AAV Particle:
DDK
  $850.00
3 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol ASCL1
Synonyms ASH1; bHLHa46; HASH1; MASH1
Vector pLenti-C-Myc-DDK
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC201123).
ACCN NM_004316
ORF Size 708 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_004316.2
RefSeq Size 2490 bp
RefSeq ORF 711 bp
Locus ID 429
UniProt ID P50553
Cytogenetics 12q23.2
Domains HLH
Protein Families Druggable Genome, Transcription Factors
MW 25.5 kDa
Summary This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. provided by RefSeq, Jul 2008
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Documents
Resources

file-alt Citations

Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells
Kudoh, Tenjin, Kameyama et al
Histochem. Cell Biol. (2020)
Cited by 39
AI Summary: OriGene’s human ASCL1 cDNA ORF clone was used to construct the ASCL1 expression plasmid (pCAG-IRES-Puro-ASCL1), enabling the study of ASCL1’s functional role in pulmonary neuroendocrine carcinoma cells.
Snippet: Bank (Osaka, Japan). Plasmid construction. To construct pCAG-IRES-Puro- ASCL1, we replicated the ASCL1 gene of a human ASCL1 cDNA ORF clone (OriGene, Rockville, Maryland) and replaced it with ASCL1. We generated
Showing 1-1 of 1 papers.
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