SOX2 (NM_003106) Human Tagged ORF Clone
$489.00
$650.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | SOX2 |
| Synonyms | ANOP3; MCOPS3 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_003106 |
| ORF Size | 951 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_003106.2, NP_003097.1 |
| RefSeq Size | 2518 bp |
| RefSeq ORF | 954 bp |
| Locus ID | 6657 |
| UniProt ID | P48431 |
| Cytogenetics | 3q26.33 |
| Protein Families | Adult stem cells, Cancer stem cells, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors |
| Summary | This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_003106" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC200757 | SOX2 (Myc-DDK-tagged)-Human SRY (sex determining region Y)-box 2 (SOX2) | 10 ug |
$450.00
|
|
| RC200757L1 | Lenti ORF clone of Human SRY (sex determining region Y)-box 2 (SOX2), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC200757L2 | Lenti ORF clone of Human SRY (sex determining region Y)-box 2 (SOX2), mGFP tagged | 10 ug |
$750.00
|
|
| RC200757L3 | Lenti ORF clone of Human SRY (sex determining region Y)-box 2 (SOX2), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC200757L4 | Lenti ORF clone of Human SRY (sex determining region Y)-box 2 (SOX2), mGFP tagged | 10 ug |
$750.00
|
|
| SC303274 | SOX2 (untagged)-Human SRY (sex determining region Y)-box 2 (SOX2) | 10 ug |
$450.00
|
|
Citations
Algorithm to improve the diagnosis of paraneoplastic neurological syndromes associated with SOX1 antibodies
Arnaldos-Pérez, Vilaseca, Naranjo et al
Front Immunol (2023) 14, 1173484 DOI: 10.3389/fimmu.2023.1173484
Arnaldos-Pérez, Vilaseca, Naranjo et al
Front Immunol (2023) 14, 1173484 DOI: 10.3389/fimmu.2023.1173484
Cited by 13
AI Summary: OriGene products contributed to this study by providing the GFP-tagged SOX1 (OriGene, RG218236), SOX2 (OriGene, RG200757), and SOX3 (OriGene, RG210859) clones used to transfect HEK293 cells for the cell-based assay, which was essential for confirming SOX1 antibody positivity in patient samples.
Snippet: es ≤10 were considered negative, values between 11 and 25 were low positive, between 26 and 50 positive, and >50 strong positive. Cell based assay Transfected HEK293 cells with the GFP-tagged SOX1(Origene, RG218236), SOX2 (Origene, RG200757) or SOX3 (Origene, RG210859) clones were fixed with 4% paraformaldehyde for 10 min, permeabilized with 0.3% Triton X-100 for 5 min, and subsequently incubat
Nanoparticle-mediated conversion of primary human astrocytes into neurons and oligodendrocytes
Li, Kozielski, Cheng et al
Biomater Sci (2016) 4 (7), 1100-12 DOI: 10.1039/c6bm00140h
Li, Kozielski, Cheng et al
Biomater Sci (2016) 4 (7), 1100-12 DOI: 10.1039/c6bm00140h
Cited by 27
AI Summary: OriGene products contributed to this study by providing the Sox2 (RC213652) and Olig2 (RC211274) expression plasmids, which were delivered into primary human astrocytes using nanoparticles to induce their conversion into neurons and oligodendrocyte progenitors.
Nanoparticle-mediated conversion of primary human astrocytes into neurons and oligodendrocytes
Li, Kozielski, Cheng et al
Biomater. Sci. (2016)
Li, Kozielski, Cheng et al
Biomater. Sci. (2016)
Showing 1-3 of 3 papers.
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