SOX2 (NM_003106) Human Untagged Clone
$450.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | SOX2 |
| Synonyms | ANOP3; MCOPS3 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_003106 |
| Insert Size | 1200 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_003106.2, NP_003097.1 |
| RefSeq Size | 2518 bp |
| RefSeq ORF | 954 bp |
| Locus ID | 6657 |
| UniProt ID | P48431 |
| Cytogenetics | 3q26.33 |
| Protein Families | Adult stem cells, Cancer stem cells, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors |
| Summary | This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_003106" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC200757 | SOX2 (Myc-DDK-tagged)-Human SRY (sex determining region Y)-box 2 (SOX2) | 10 ug |
$450.00
|
|
| RC200757L1 | Lenti ORF clone of Human SRY (sex determining region Y)-box 2 (SOX2), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC200757L2 | Lenti ORF clone of Human SRY (sex determining region Y)-box 2 (SOX2), mGFP tagged | 10 ug |
$750.00
|
|
| RC200757L3 | Lenti ORF clone of Human SRY (sex determining region Y)-box 2 (SOX2), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC200757L4 | Lenti ORF clone of Human SRY (sex determining region Y)-box 2 (SOX2), mGFP tagged | 10 ug |
$750.00
|
|
| RG200757 | SOX2 (tGFP-tagged) - Human SRY (sex determining region Y)-box 2 (SOX2) | 10 ug |
$489.00
$650.00
|
|
Citations
The function of SOX2 in breast cancer and relevant signaling pathway
Meng, Xu, Chen et al
Pathology - Research and Practice (2020) 216 (8), 153023 DOI: 10.1016/j.prp.2020.153023
Meng, Xu, Chen et al
Pathology - Research and Practice (2020) 216 (8), 153023 DOI: 10.1016/j.prp.2020.153023
Cited by 17
SOX2 activation predicts prognosis in patients with head and neck squamous cell carcinoma
Chung, Jung, Jung et al
Sci Rep (2018) 8 (1), 1677 DOI: 10.1038/s41598-018-20086-w
Chung, Jung, Jung et al
Sci Rep (2018) 8 (1), 1677 DOI: 10.1038/s41598-018-20086-w
AI Summary: OriGene products, specifically the SOX2 overexpression plasmid (pCMV6-XL5-SOX2, NM_003106.2) and the empty vector control (pCMV6_XL5), were used to manipulate SOX2 expression in HNSCC cells, enabling the study of SOX2's role in prognosis and response to radiotherapy in head and neck squamous cell carcinoma.
Showing 1-2 of 2 papers.
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