EVER2 (TMC8) (NM_152468) Human Tagged ORF Clone
$997.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | EVER2 |
| Synonyms | EV2; EVER2; EVIN2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_152468 |
| ORF Size | 2178 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_152468.5 |
| RefSeq Size | 4419 bp |
| RefSeq ORF | 2181 bp |
| Locus ID | 147138 |
| UniProt ID | Q8IU68 |
| Cytogenetics | 17q25.3 |
| Protein Families | Transmembrane |
| MW | 82.1 kDa |
| Summary | Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_152468" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC210309L1 | Lenti-ORF clone of TMC8 (Myc-DDK-tagged)-Human transmembrane channel-like 8 (TMC8) | 10 ug |
$1,297.00
|
|
| RC210309L2 | Lenti-ORF clone of TMC8 (mGFP-tagged)-Human transmembrane channel-like 8 (TMC8) | 10 ug |
$1,297.00
|
|
| RC210309L3 | Lenti-ORF clone of TMC8 (Myc-DDK-tagged)-Human transmembrane channel-like 8 (TMC8) | 10 ug |
$1,297.00
|
|
| RC210309L4 | Lenti-ORF clone of TMC8 (mGFP-tagged)-Human transmembrane channel-like 8 (TMC8) | 10 ug |
$1,297.00
|
|
| RG210309 | TMC8 (tGFP-tagged) - Human transmembrane channel-like 8 (TMC8) | 10 ug |
$1,197.00
|
|
| SC101329 | TMC8 (untagged)-Human transmembrane channel-like 8 (TMC8) | 10 ug |
$1,890.00
|
|
Citations
The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses
de Jong, Créquer, Matos et al
J Exp Med (2018) 215 (9), 2289-2310 DOI: 10.1084/jem.20170308
de Jong, Créquer, Matos et al
J Exp Med (2018) 215 (9), 2289-2310 DOI: 10.1084/jem.20170308
Cited by 133
AI Summary: In this study, OriGene products—including the CIB1 (RC208307), TMC6/EVER1 (RC217753), and TMC8/EVER2 (RC208305) expression plasmids—were used to investigate the interactions and functional roles of these proteins in keratinocyte immunity to β-papillomaviruses.
Showing 1-1 of 1 papers.
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