PROX1 (NM_002763) Human Tagged ORF Clone
$1,013.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | PROX1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_002763 |
| ORF Size | 2211 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002763.5 |
| RefSeq Size | 8178 bp |
| RefSeq ORF | 2214 bp |
| Locus ID | 5629 |
| UniProt ID | Q92786 |
| Cytogenetics | 1q32.3 |
| Domains | Prox1 |
| Protein Families | Embryonic stem cells, ES Cell Differentiation/IPS |
| MW | 83.2 kDa |
| Summary | The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2012 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002763" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC201140L1 | Lenti ORF clone of Human prospero homeobox 1 (PROX1), Myc-DDK-tagged | 10 ug |
$1,313.00
|
|
| RC201140L2 | Lenti ORF clone of Human prospero homeobox 1 (PROX1), mGFP tagged | 10 ug |
$1,313.00
|
|
| RC201140L3 | Lenti ORF clone of Human prospero homeobox 1 (PROX1), Myc-DDK-tagged | 10 ug |
$1,313.00
|
|
| RC201140L4 | Lenti ORF clone of Human prospero homeobox 1 (PROX1), mGFP tagged | 10 ug |
$1,313.00
|
|
| RG201140 | PROX1 (tGFP-tagged) - Human prospero homeobox 1 (PROX1) | 10 ug |
$1,213.00
|
|
| SC318217 | PROX1 (untagged)-Human prospero homeobox 1 (PROX1) | 10 ug |
$1,013.00
|
|
Citations
Suppression of PROX1-mediated TERT expression in hepatitis B viral hepatocellular carcinoma
Kim, Yoo, Jeon et al
Int. J. Cancer (2018)
Kim, Yoo, Jeon et al
Int. J. Cancer (2018)
PROX1 promotes human glioblastoma cell proliferation and invasion via activation of the nuclear factor-κB signaling pathway
Xu, Wan, Wei
Mol Med Rep (2017) 15 (2), 963-968 DOI: 10.3892/mmr.2016.6075
Xu, Wan, Wei
Mol Med Rep (2017) 15 (2), 963-968 DOI: 10.3892/mmr.2016.6075
AI Summary: OriGene’s full-length human PROX1 cDNA was used to overexpress PROX1 in glioblastoma cell lines, enabling the study of its role in promoting cell proliferation and invasion via the NF-κB signaling pathway.
Snippet: 964 Plasmids and transfection. Full-length human PROX1 cDNA (OriGene Technologies, Inc., Rockville, MD, USA) was cloned into the expression vector pcDNA3.1(+) (Invitrogen;Thermo Fisher Scientific, Inc.). The sequence
PROX1 Gene is Differentially Expressed in Oral Cancer and Reduces Cellular Proliferation
Rodrigues, de Oliveira Rodini, de Aquino Xavier et al
Medicine (Baltimore) (2014) 93 (28), e192 DOI: 10.1097/MD.0000000000000192
Rodrigues, de Oliveira Rodini, de Aquino Xavier et al
Medicine (Baltimore) (2014) 93 (28), e192 DOI: 10.1097/MD.0000000000000192
AI Summary: OriGene’s pCMV6-PROX1 expression vector was used to stably overexpress the PROX1 gene in SCC9 oral cancer cells, enabling the study of PROX1’s role in cellular proliferation and tumor suppression.
Snippet: SCC9 cells were transfected with pCMV6 empty vector (mock) or pCMV6-PROX1 expression vector (OriGene, Rockville, MD), containing full-length human PROX1 cDNA, using Lipofectamine 2000 (Invitrogen), following the manufacturer's instructions. Transfected cells were selected in medium with 300 μg/mL G418 (Invitrogen)
Showing 1-3 of 3 papers.
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