Fgfr4 (NM_008011) Mouse Tagged ORF Clone
$1,097.00
5 Days*
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
|---|---|
| Target Symbol | Fgfr4 |
| Synonyms | Fgfr-4 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_008011 |
| ORF Size | 2397 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_008011.2, NP_032037.2 |
| RefSeq Size | 3146 bp |
| RefSeq ORF | 2400 bp |
| Locus ID | 14186 |
| UniProt ID | Q03142, A0A0R4IZY3 |
| Cytogenetics | 13 29.8 cM |
| MW | 89 kDa |
| Summary | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages.UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_008011" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MC221681 | Fgfr4 (untagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4), (10ug) | 10 ug |
$806.00
|
|
| MG210769 | Fgfr4 (tGFP-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) | 10 ug |
$1,297.00
|
|
| MR210769L1 | Lenti ORF clone of Fgfr4 (Myc-DDK-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) | 10 ug |
$1,397.00
|
|
| MR210769L2 | Lenti ORF clone of Fgfr4 (mGFP-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) | 10 ug |
$1,397.00
|
|
| MR210769L3 | Lenti ORF clone of Fgfr4 (Myc-DDK-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) | 10 ug |
$1,397.00
|
|
| MR210769L4 | Lenti ORF clone of Fgfr4 (mGFP-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) | 10 ug |
$1,397.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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