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Fgfr4 (NM_008011) Mouse Untagged Clone

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SKU
MC221681
Fgfr4 (untagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4), (10ug)
Interest in protein/lysate? Submit request here!
ORF Plasmid:
Tag Free tGFP DDK
AAV Particle:
DDK
  $806.00
5 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Fgfr4
Synonyms Fgfr-4
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC221681 representing NM_008011
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGTGGCTGCTCTTGGCCCTGTTGAGCATCTTTCAGGGGACACCAGCTTTGTCCCTTGAGGCCTCTGAGG
AAATGGAGCAGGAGCCCTGCCTAGCCCCAATCCTGGAGCAGCAAGAGCAGGTGTTGACGGTGGCCCTGGG
GCAGCCTGTGAGGCTGTGCTGTGGGCGCACCGAGCGTGGTCGTCACTGGTACAAAGAGGGCAGCCGCCTA
GCATCTGCTGGGCGAGTACGGGGTTGGAGAGGCCGCCTGGAGATCGCCAGCTTCCTTCCTGAGGATGCTG
GCCGATACCTCTGCCTGGCCCGTGGCTCCATGACCGTCGTACACAATCTTACGTTGCTTATGGATGACTC
CTTAACCTCCATCAGTAATGATGAAGACCCCAAGACACTCAGCAGCTCCTCGAGTGGTCATGTCTACCCA
CAGCAAGCACCCTACTGGACACACCCCCAACGCATGGAGAAGAAACTGCATGCAGTGCCTGCCGGGAATA
CTGTCAAATTCCGCTGTCCAGCTGCAGGGAACCCCATGCCTACCATCCACTGGCTCAAGGATGGACAGGC
CTTCCACGGGGAGAATCGTATTGGAGGCATTCGGCTGCGCCACCAACACTGGAGCCTGGTGATGGAAAGT
GTGGTACCCTCGGACCGTGGCACATACACATGCCTTGTGGAGAACTCTCTGGGTAGCATTCGCTACAGCT
ATCTCCTGGATGTGCTGGAGCGGTCCCCGCACCGGCCCATCCTGCAGGCGGGGCTCCCAGCCAACACCAC
AGCTGTGGTTGGCAGCGATGTGGAGCTACTCTGCAAGGTGTACAGCGACGCCCAGCCCCACATACAGTGG
CTGAAACACGTCGTCATCAACGGCAGCAGCTTCGGCGCCGACGGTTTCCCCTACGTACAAGTCCTGAAGA
CAACAGACATCAATAGCTCGGAGGTAGAGGTCTTGTATCTGAGGAACGTGTCCGCTGAGGATGCAGGAGA
GTATACCTGTCTGGCGGGCAACTCCATCGGCCTTTCCTACCAGTCAGCGTGGCTCACGGTGCTGCCAGAG
GAAGACCTCACGTGGACAACAGCAACCCCTGAGGCCAGATACACAGATATCATCCTGTATGTATCAGGCT
CACTGGTTCTGCTTGTGCTCCTGCTGCTGGCCGGGGTGTATCATCGGCAAGTCATCCGTGGCCACTACTC
TCGCCAGCCTGTCACTATACAAAAGCTGTCCCGTTTCCCTTTGGCCCGACAGTTCTCTTTGGAGTCGAGG
TCCTCTGGCAAGTCAAGTTTGTCCCTGGTGCGAGGTGTCCGTCTCTCCTCCAGCGGCCCGCCCTTGCTCA
CGGGCCTTGTGAATCTAGACCTGCCTCTCGATCCGCTTTGGGAATTCCCCCGGGACAGGTTGGTGCTCGG
AAAGCCCCTGGGTGAGGGCTGCTTTGGGCAAGTGGTTCGTGCAGAGGCCTTTGGTATGGATCCCTCCCGG
CCCGACCAAACCAGCACCGTGGCTGTGAAGATGCTGAAAGACAATGCCTCCGACAAGGATTTGGCAGACC
TGGTCTCCGAGATGGAGGTGATGAAGCTAATCGGAAGACACAAGAACATCATCAACCTGCTGGGTGTCTG
CACTCAGGAAGGGCCCCTGTACGTGATTGTGGAATGTGCCGCCAAGGGAAACCTTCGGGAATTCCTCCGT
GCCCGGCGCCCCCCAGGCCCTGATCTCAGCCCTGATGGACCTCGGAGCAGCGAAGGACCACTCTCCTTCC
CGGCCCTAGTCTCCTGTGCCTACCAGGTGGCCCGAGGCATGCAGTATCTGGAGTCTCGGAAGTGCATCCA
CCGGGACCTGGCTGCCCGAAATGTGCTGGTGACCGAGGATGATGTGATGAAGATCGCTGACTTTGGGCTG
GCACGTGGTGTCCACCACATTGACTACTATAAGAAAACCAGCAACGGCCGCCTGCCAGTCAAATGGATGG
CTCCAGAGGCATTGTTCGACCGCGTGTACACACACCAGAGTGACGTGTGGTCTTTCGGGATCCTGCTGTG
GGAAATCTTCACCCTCGGGGGCTCCCCATACCCTGGCATTCCGGTGGAGGAGCTCTTCTCACTGCTGCGA
GAGGGGCACAGGATGGAGCGGCCCCCAAACTGCCCCTCAGAGCTGTATGGGCTAATGAGGGAGTGCTGGC
ACGCAGCCCCATCTCAGAGGCCTACTTTTAAGCAGCTGGTGGAAGCTCTGGACAAGGTCCTGCTGGCTGT
CTCTGAAGAGTACCTTGACCTCCGCCTGACCTTTGGACCCTTTTCTCCCTCCAATGGGGATGCCAGCAGC
ACCTGCTCCTCCAGTGACTCGGTTTTCAGCCACGACCCTTTGCCCCTCGAGCCAAGCCCCTTCCCTTTCT
CTGACTCGCAGACGACATGA

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_008011
Insert Size 2400 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_008011.2, NP_032037.2
RefSeq Size 3146 bp
RefSeq ORF 2400 bp
Locus ID 14186
UniProt ID Q03142
Cytogenetics 13 29.8 cM
Summary Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages.UniProtKB/Swiss-Prot Function
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"NM_008011" in other vectors (6)
SKU Description Size Price
MG210769 Fgfr4 (tGFP-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) 10 ug
$1,297.00
MR210769 Fgfr4 (Myc-DDK-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) 10 ug
$1,097.00
MR210769L1 Lenti ORF clone of Fgfr4 (Myc-DDK-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) 10 ug
$1,397.00
MR210769L2 Lenti ORF clone of Fgfr4 (mGFP-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) 10 ug
$1,397.00
MR210769L3 Lenti ORF clone of Fgfr4 (Myc-DDK-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) 10 ug
$1,397.00
MR210769L4 Lenti ORF clone of Fgfr4 (mGFP-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4) 10 ug
$1,397.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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