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Fgfr4 (NM_008011) Mouse Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
MR210769L3V
Lenti ORF particles, Fgfr4 (Myc-DDK-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4), 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
tGFP DDK
Lentiviral Particles:
DDK w/ Puro DDK mGFP mGFP w/ Puro
  $1,647.00
2 Weeks*
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Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol Fgfr4
Synonyms Fgfr-4
Vector pLenti-C-Myc-DDK-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(MR210769).
ACCN NM_008011
ORF Size 2397 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_008011.2, NP_032037.2
RefSeq Size 3146 bp
RefSeq ORF 2400 bp
Locus ID 14186
UniProt ID Q03142, A0A0R4IZY3
Cytogenetics 13 29.8 cM
Summary Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages.UniProtKB/Swiss-Prot Function
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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