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Phlpp2 (NM_001122594) Mouse Untagged Clone

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SKU
MC224335
Phlpp2 (untagged) - Mouse PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), (10ug)
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ORF Plasmid:
Tag Free tGFP DDK
  $1,276.00
8 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Phlpp2
Synonyms AI481772; C130044A18Rik; Phlppl
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC224335 representing NM_001122594
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGGGGAGGTGGAGCCCGTGCCCGCGGGCCCGCTGGAGCCCCCGGAGCCACCTGAAGCGGCGGCGCCTC
GCCGGCCCGGAGGGATTCGGGTCCTAAAGAGAAATATGAAACACAATGGGAGCAGAACTTGTTTGAATAG
AAGAAGTAGGTTTGGTTCCCGAGAAAGAGACTGGCTAAGAGAAGATGTGAAGAGAGGCTGTGTTTACCTT
TATGGAGCAGACACGACCACTGCCACTACAACCACCTCCTCCTCCTCCTCCTCCTCCTCCTCTTCTGATT
TACATCTTGTCCTTTGCACAGTAGAGACACCAGCGTCAGAAATATGTGCTGGAGAGGGAAGAGAAAGCCT
CTATCTACAGCTTCATGGAGATCTGGTCAGGAGACTGGAGCCCTCTGAACGGCCTCTCCAGATTGTTTAC
GATTACTTATCCAGGCTGGGGTTTGAAGATCCCGTGCGCATACAGGAGGAGGCTACGAACCCTGACCTCA
GCTGTATGATTCGATTTTATGGTGAAAAACCATGCCAGATGGATCATCTGGATCGAATCCTACTGTCTGG
CATCTATAATGTACGCAAAGGAAAAACCCAGCTGCACAAATGGGCTGAGCGCCTCGTTGTTCTCTGTGGT
ACCTGCCTTATTGTTTCCTCAGTGAAGGATTGTCAAACTGGAAAGATGCACATTTTGCCGCTGGTTGGGG
GAAAGATAGAAGAAGTGAAGCGCCGGCAGCACTCCCTTGCTTTCAGCTCAGCTGGAGCCCAAGCTCAGAC
CTATCATGTCAGCTTTGAGACTTTGGCTGAGTACCAGAGATGGCAACGGCAGGCGTCTAAGGTGGTGTCG
CAGCGGATGAGCACTGTGGACCTCTCATGCTACAGCCTTGAAGAGGTTCCTGAGCATCTCTTCTACAGCC
AAGACATCACCTACCTCAACCTGCGGCACAACTTCATGCAGCTAGAAAGACCAGGGGGCCTTGACACACT
CCACAAATTTTCTCAACTGAAGGGCCTGAACTTGTCCCATAATAAACTTGGACTGTTTCCTGTGCTGCTG
TGTGAGATTTCTACCCTGACTGAGCTCAGCCTTTCTTGTAATGGATTTCATGACTTGCCAAGTCAGATTG
GTAAATTGCTAAATCTTCAGACCCTCAGCCTCGACGGCAACGGCCTCACGGCTCTGCCAGATGAGTTGGG
AAACCTGCGGCAGCTCACTTCTCTGGGAATTTCCTTCAACGATTTTCGTCACATCCCTGAAGTTTTGGAG
AAACTTACCATGTTAGATAAAGTGGCTATGGCAGGAAACCGTTTGGAGGTCCTGAACCTGGGGGCACTGA
CCAGGATGAGCCAGGTCAAGCACGTGGATCTGAGGATGAACCACTTGAAAACGGTGATTACTGAAAATAT
GGAAGGAAATAAACATATCACGCACATGGATTTGCGGGACAATCAGTTGACTGATTTGGACCTTAGCTCC
TTATGTAGCTTGGAGCAGCTGCACTGTGAGCGGAACCAGCTGAGGGAGCTGACACTCAGCGGCTTCTCCC
TTCGAACCCTCTACGCCAGTTGGAACAGGCTGACGGCAGTGAATGTGTACCCAGTGCCCAGCCTGCTCAC
TTCTTTGGAGCTCTCCCAAAACTTGCTGGAGTGTGTCCCTGACTGGGCCTGTGAAGCAAAAAAGCTGGAA
ATACTAGACATAAGCCACAATCTTCTTACAGAGGTCCCCATGAGAATTCTGAGTAGTCTGAGTCTTCGGA
AACTGATGGTAGGACACAATCACATCCATGTCCTTCCTGCACTGGTGGAGCACATTCCCCTCGAGGTCCT
GGATATCCAGCATAACACTCTCTCCAGGCTGCCGGACACGCTCTTCTCCAAGGCCTTAAATCTCAGGTAC
TTGAATGCATCTGCAAATAGTCTGGAGTCCTTGCCTTCTGCGTGTGCTGGAGAGGAGAGTCTGAGTGTGC
TGCAGCTGCTGTACCTGACCAGCAACCTTCTGACAGATCAGTGCATACCAGTTTTGGTCGGGCACCCACA
CCTGCGAGTTCTGCACCTTGCAAACAACCAGCTCCAGACCTTCCCTGCAAGCAAGCTAAATAAACTGGAG
CAGCTGGAAGAGCTGAATCTAAGTGGGAACAAACTTACAGCTATCCCCACAACCATAGCCAACTGCAAAA
GGCTGCACACCCTTGTCGCCCATGCCAACAACATCAGCATCTTCCCAGAGATCCTGCAGCTGCCTCAGAT
TCAGTTTGTAGACCTGAGTTGCAATGACTTGACAGAAATCCTAATTCCAGAAGCTCTGCCTGCTACTTTA
CAAGACCTTGATCTGACAGGAAATACAAATCTGGTCCTGGAACATAAGACTTTGGACATGTTTAGCCACA
TCACAGCCCTGAAGATTGATCAGAAGCCTTTGCCAGCCACAGACTCTGCAGTTACATCAACCTTCTGGAG
CCATGGCCTGGCCGAGATGGCAGGGCAGAGGAATAAACTCTGTGTGTCTGCCCTGGCTATGGATAACTTT
GCAGAGGGTGTGGGAGCTGTCTACGGCATGTTTGATGGGGACCGGAATGAAGAACTCCCTCGTCTGCTGC
AGTGTACAATGGCAGATGTGCTTTTGGAAGAAGTACAGCACTCAACAAATGACACAGTTTTCATGACCAA
TACCTTCTTGGTATCTCACAGGAAATTAGGAATGGCTGGCCAGAAGCTGGGTTCTTCGGCTCTCCTGTGC
TATATTCGACCTGACACTGCCGACCCAACAAGTAGCTTTAGCTTGACTGTAGCCAATGTTGGCATGTGCC
AAGCTGTCCTGTGCCGAGGTGGGAAGCCAGTACCTCTTTCTAAAGTCTTCAGCTTGGAGCATGACCCAGA
GGAGGCTCAGAGGGTGAAAGACCAGAAAGCCATCATAACAGAGGACAACAAGGTGAACGGAGTAACCTGC
TGCACCCGGCTGCTGGGGTGCACATACCTCTACCCATGGATCCTCCCCAAGCCCCACATAGCTTCCACTC
CACTTACCATTCAAGATGAATTGCTGATTTTGGGAAACAAAGCACTGTGGGAACACTTGTCATATCTAGA
AGCTGTCAATGCAGTACGTCACGTGCAAGACCCACTAGCTGCTGCTAAGAAGCTGTGCACATTAGCCCAG
AGCTACGGTTGTCAGGACAACGTGGGGGCAATGGTGGTTTATTTGAATATTGGTGAAGAAGGCTGTACCT
GTGAAATGAATGGGCTCACCCTTCCAGGCCCTGTGGGATTTGCTTCAACTGCAGCCCTCAAGGATACTCC
CAAGCCAACCACTCCCTCCTCCAGTAGTGGGATTGCCTCCGAGTTCAGCAGTGAGATGTCCACCTCAGAG
GTGAGCAGTGAAGTGGGCTCCACGGCCTCGGATGAGCACAACACTGTGGGCCTGGAGGCGAGCTTGCTGC
CCAGGCCAGAGAGGCGCTGCAGTCTGCACCCAGCGTCCTCCGCAGGGGTGTTCCAGCGCCAGCCTTCTTG
TGCTACTTTTTCCAGCAATCAGTCTGACAATGGCCTGGACAGTGACGATGACCAGCCTGTTGAAGGAGTC
ATAACCAACGGCAGCAGGGTTGAAGTAGAGGTAGACATCCATTGCTGCCGAGGCAGAGAGCCAGAGAGCT
CCCCTCCGCTCCCGAAGAACTCTTCCAACGCCTGTTCAGAGGAGCGTGCTAGAGGGGCGGGGTTTGGGAT
CCGAAGACAGAACAGTGTCAACAGTGGTATACTTCTGCCAGCGAACAGAGACAAGATGGAGCTGCAGAAG
TCTCCCTCCACTTCTTGTCTGTATGGAAAGAAACTCTCCAATGGCTCCATTGTGCCCCTAGAGGACAGCC
TGAACCTCATTGAGGTGGCCACAGAAGCACCCAAAAGGAAAACTGGCTACTTTGCTGCCCCCACTCAGCT
GGAACCAGAGGATCAGTTTGTCGTCCCTCGAGACCTGGAAGAGGAAGTGAAGGAGCAGATGAAGCAGCAC
CAGGAGGGCAGGCCTGAGCCCGAGCCCCGGGGAGAGGAGCGGACAGAGCCCCTGGAGGAGTTTGATACAG
CACTGTGA

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_001122594
Insert Size 4068 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001122594.2, NP_001116066.2
RefSeq Size 7854 bp
RefSeq ORF 4068 bp
Locus ID 244650
UniProt ID Q8BXA7
Cytogenetics 8 D3
Summary Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_001122594" in other vectors (4)
SKU Description Size Price
MG219729 Phlpp2 (tGFP-tagged) - Mouse PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), (10ug) 10 ug
$1,359.00
MR219729 Phlpp2 (Myc-DDK-tagged) - Mouse PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2) 10 ug
$589.00 $1,159.00
MR219729L3 Lenti ORF clone of Phlpp2 (Myc-DDK-tagged) - Mouse PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2) 10 ug
$1,459.00
MR219729L4 Lenti ORF clone of Phlpp2 (mGFP-tagged) - Mouse PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2) 10 ug
$1,459.00

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