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Six1 (NM_009189) Mouse Untagged Clone

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SKU
MC201713
Six1 (untagged) - Mouse sine oculis-related homeobox 1 homolog (Drosophila) (Six1), (10ug)
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ORF Plasmid:
Tag Free tGFP DDK
  $300.00
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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Six1
Synonyms BB138287
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>BC023304 sequence for NM_009189
CAGCAGCATCCACCCGGCGGCAGGCGGGAGCCAGCGAGGCCCAGAAGGCTGTAGAGAACGCCAGCCACTC GGAGTCTAGCTCACCCCTACTTCTCTTCGTCTTCCTTGGCCTCCCACCCGCCGAGGTTCGACTGGTCTCT TCGCCCGCGCCAAGGCTAGGGAGGGGGTTAGGAGCAGCCGCGCCCCCCTCCCCGCGGCAGCCGCCCCCTG CTCTCCCAGCTCTGCTCACTGCCGCGTGCGCCCGGGCCCGTGCGCCCCGGCAGCGCCAGCCATGTCGATG CTGCCGTCGTTTGGTTTTACGCAAGAGCAAGTGGCGTGCGTGTGCGAAGTTCTGCAGCAAGGAGGGAACC TGGAACGCCTGGGCAGGTTCTTGTGGTCGTTGCCCGCCTGCGATCACCTGCACAAGAACGAGAGCGTGCT CAAGGCCAAGGCGGTGGTCGCCTTCCACCGCGGCAACTTCCGCGAGCTCTACAAGATACTGGAGAGCCAC CAGTTCTCGCCTCACAATCACCCCAAACTGCAGCAGCTGTGGCTGAAAGCGCACTACGTGGAGGCCGAGA AACTTCGCGGCCGACCCCTGGGTGCCGTGGGCAAATATCGGGTGCGCCGAAAATTCCCGTTGCCGCGGAC CATCTGGGACGGCGAGGAGACCAGCTACTGCTTTAAGGAGAAGTCTCGGGGCGTGCTGCGGGAGTGGTAC GCGCACAACCCCTACCCCTCACCGAGGGAGAAACGGGAGCTGGCCGAGGCCACCGGCCTCACCACCACCC AGGTCAGCAACTGGTTTAAGAACCGGAGGCAAAGAGACCGGGCCGCCGAGGCCAAGGAAAGGGAGAACAC CGAAAACAATAACTCCTCCTCCAACAAGCAGAATCAACTCTCTCCTCTGGAAGGGGGCAAGCCGCTCATG TCCAGCTCAGAAGAGGAGTTCTCACCCCCCCAAAGTCCAGACCAGAACTCGGTCCTTCTGCTCCAGAGCA ATATGGGCCACGCCAGGAGCTCAAACTATTCTCTTCCAGGCCTCACAGCCTCCCAGCCCAGCCACGGTCT GCAAGCCCATCAGCACCAGCTCCAGGACTCTCTGCTGGGCCCACTCACCTCCAGTTTGGTGGACTTGGGT TCCTAAGTGGGGAGATATTGGGGCCTTGAAGGGATGGCCGGAGCAGCAACCAACCGCAGCAATCTAGGGG ACACTTGTACATAGAAGCCAGGGACAATTCTGCAGCTTGTTTCTGGGGTTCTTTGCGCAGAAAGGAACCA CAGGCTTTCACAATTGTCTTTTTAAAAATTACAACCAACAGCGGTCTCAGTTGAGCATCCTCTCCCTCCT CTCCAACTCTTAATACCCTTGCATTTCCCCTCCCACTAAAAGGTCAGGAAATAACAAAAACAGCCAGGCT TGGTTCTGGGCAACCCAGGCATCCTTTACAGTAGTCCCTTATTCCACCTCTTCTTCCTCCTCCTCCTCGT CTTCTTTTAATGAACAGAAATTACAAATCAGCTGGATTGTAATTATTTTTTTAATTTATTTATGGAGAAA CGGTTTAGGGAAGAGGAAAAGGAAATGAAGAGAGATCAAAATAATGAAAACAAGAAACCTTCAGTGTGAG GGGAACTGGCTGCCTTCTTAAGACAAATAGGAAAACTATAATCACAGCTGTTTTTTGATGGGAAGATTAA GTTTACATTTTTCATATTTAGTGTTAAATAATTTTATGTAGATTAAAATAAAAGAGCAGTATTAGCAAGG GAAACAAGTGCCTAAATGTCTTAATGCTCTCTATGGGAGGCGGTTAGGGTAGCAGCGATGTTAGTAATAC AACTATTTTTGTCAAATTTAATAGGGGTTTTGGTGATTGTTTTCTTGTTTTGTTTTGTTTTTTAATTTTT ATGACAAACTCTAAACGTGTACCAACGAGGGAGGGGGAAAACCCGCTTTCCTAAATGTCATCAGTTCTTC CTCAGAAACTCTCCTATCTGTAGGCTGCCTCTGTGCAGAGGGCTCTGCTACTACTCCTAGTTCCTACTTA CAAGAGGGTGCCAACCAATCTGGCAGCCCGGTGTTTGTTACTAAAACAGCATGTGTTTTTAGGCCTCCTT TCTATTGTACCTAAACCAGTCTAAATTAAAACTCAGTAGCCCAGCAGGAAAAAAAAAAAAAAAAAAAAAA
Restriction Sites RsrII-NotI |
ACCN NM_009189
Insert Size 855 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq BC023304, AAH23304
RefSeq Size 2170 bp
RefSeq ORF 855 bp
Locus ID 20471
UniProt ID Q62231
Cytogenetics 12 30.34 cM
Summary Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCAAGAGTTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2.UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_009189" in other vectors (4)
SKU Description Size Price
MG203850 Six1 (tGFP-tagged) - Mouse sine oculis-related homeobox 1 homolog (Drosophila) (Six1) 10 ug
$650.00
MR203850 Six1 (Myc-DDK-tagged) - Mouse sine oculis-related homeobox 1 homolog (Drosophila) (Six1) 10 ug
$450.00
MR203850L3 Lenti ORF clone of Six1 (Myc-DDK-tagged) - Mouse sine oculis-related homeobox 1 homolog (Drosophila) (Six1) 10 ug
$750.00
MR203850L4 Lenti ORF clone of Six1 (mGFP-tagged) - Mouse sine oculis-related homeobox 1 homolog (Drosophila) (Six1) 10 ug
$750.00

file-alt Citations

Role of the PRC2-Six1-miR-25 signaling axis in heart failure
Oh, Jang, Yoo et al
J. Mol. Cell. Cardiol. (2019) 129, 58-68 DOI: 10.1016/j.yjmcc.2019.01.017
AI Summary: OriGene’s full-length mouse Six1 cDNA (NM_009189) was used to generate transgenic mice, enabling the study of Six1’s role in the regulation of miR-25 and cardiac dysfunction in heart failure.
Snippet: 4.1.2. Generation of Tg mice. Full-length mouse Six1 cDNA (NM_009189;OriGene) with the human growth hormone 3′ UTR and a 5.5 kb segment of the α-MHC promoter was constructed and microinjected into FVB fertilized eggs;
Showing 1-1 of 1 papers.
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