Six1 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Reactivity | Mouse |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Specificity | Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish Homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100% |
| Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 32kDa |
| Gene Name | sine oculis-related homeobox 1 |
| Database Link | |
| Background | Six1 is a transcription factor that is involved in regulation of organogenesis. It seems to be required for development of kidney, muscle and inner ear and to be involved in later steps of myogenic differentiation. It may be involved in limb tendon and ligament development. It binds a 5'-TCAAGAGTTNC-3' motif present in the MEF3 element in the myogenin promoter. It is thought to be regulated by association with Dach and Eya proteins. Six1 acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 phosphatase to the SIX1-DACH1 complex. During myogenesis, Six1 seems to act together with EYA2 and DACH2 . |
| Synonyms | BOS3; DFNA23; TIP39 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Nervous system Diseases, Transciption Factors |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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