Dopamine D2 Receptor (DRD2) (NM_016574) Human Tagged ORF Clone
$289.00
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | Dopamine D2 Receptor |
| Synonyms | D2DR; D2R |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_016574 |
| ORF Size | 1242 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_016574.3 |
| RefSeq Size | 2556 bp |
| RefSeq ORF | 1245 bp |
| Locus ID | 1813 |
| UniProt ID | P14416, A0A024R3I6 |
| Cytogenetics | 11q23.2 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Gap junction, Neuroactive ligand-receptor interaction |
| MW | 47.2 kDa |
| Summary | This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_016574" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC213065L1 | Lenti ORF clone of Human dopamine receptor D2 (DRD2), transcript variant 2, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC213065L2 | Lenti ORF clone of Human dopamine receptor D2 (DRD2), transcript variant 2, mGFP tagged | 10 ug |
$757.00
|
|
| RC213065L3 | Lenti ORF clone of Human dopamine receptor D2 (DRD2), transcript variant 2, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC213065L4 | Lenti ORF clone of Human dopamine receptor D2 (DRD2), transcript variant 2, mGFP tagged | 10 ug |
$757.00
|
|
| RG213065 | DRD2 (tGFP-tagged) - Human dopamine receptor D2 (DRD2), transcript variant 2 | 10 ug |
$489.00
$657.00
|
|
| SC308892 | DRD2 (untagged)-Human dopamine receptor D2 (DRD2), transcript variant 2 | 10 ug |
$457.00
|
|
Citations
Modulation of huntingtin S421 phosphorylation in a Huntington's disease mouse model and its detection in nonhuman primate cerebrospinal fluid
Verani, Martufi, Petricca et al
bioRxiv (2025)
Verani, Martufi, Petricca et al
bioRxiv (2025)
AI Summary: OriGene contributed to this study by providing the pCMV6 expression plasmids for the C-term Myc-FLAG-tagged dopamine D2 receptor (D2R; catalog #RC213065) and Protein kinase A catalytic subunit (PRKACA; catalog #RC210332), which were used to investigate the phosphorylation of huntingtin at S421 in cellular assays.
Snippet: The pCMV6 expression plasmids containing the cDNA coding for C-term Myc-FLAG-tagged dopamine D2 receptor (D2R;catalog #RC213065) and Protein kinase A catalytic subunit (PKA Cα) (PRKACA;catalog #RC210332) were obtained from ORIGENE (Rockville, Maryland, United States)
PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate
Lin, Qi, Chu et al
Nat Commun (2025) 16 (1), 6736 DOI: 10.1038/s41467-025-62111-3
Lin, Qi, Chu et al
Nat Commun (2025) 16 (1), 6736 DOI: 10.1038/s41467-025-62111-3
Cited by 7
AI Summary: OriGene products contributed pCMV6 expression plasmids encoding C-term Myc-FLAG-tagged dopamine D2 receptor (D2R; RC213065) and Protein kinase A catalytic subunit (PRKACA; RC210332), which were used for protein expression studies in the investigation of PFKM’s role in mitotic progression.
Snippet: The pCMV6 expression plasmids containing the cDNA coding for C-term Myc-FLAG-tagged dopamine D2 receptor (D2R;catalog #RC213065) and Protein kinase A catalytic subunit (PKA Cα) (PRKACA;catalog #RC210332) were obtained from ORIGENE (Rockville, Maryland, United States)
Ultrasensitive multiplexed detection of cancer biomarker proteins using SPR imaging
Ozkaya, Durak, Sharafeldin et al
Microchemical Journal (2025) 216, 114562-114562 DOI: 10.1016/j.microc.2025.114562
Ozkaya, Durak, Sharafeldin et al
Microchemical Journal (2025) 216, 114562-114562 DOI: 10.1016/j.microc.2025.114562
Cited by 5
AI Summary: In this study, OriGene's pCMV6 expression plasmids encoding Myc-FLAG-tagged dopamine D2 receptor (D2R; RC213065) and protein kinase A catalytic subunit (PRKACA; RC210332) were used to produce target proteins for ultrasensitive multiplexed detection of cancer biomarkers.
Snippet: The pCMV6 expression plasmids containing the cDNA coding for C-term Myc-FLAG-tagged dopamine D2 receptor (D2R;catalog #RC213065) and Protein kinase A catalytic subunit (PKA Cα) (PRKACA;catalog #RC210332) were obtained from ORIGENE (Rockville, Maryland, United States)
Showing 1-3 of 3 papers.
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