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PDGF Receptor beta (PDGFRB) (NM_002609) Human Tagged Lenti ORF Clone

  • LentiORF®
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SKU
RC206377L4
Lenti ORF clone of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB), mGFP tagged
ORF Plasmid:
mGFP DDK DDK-His tGFP
Lentiviral Particles:
DDK mGFP DDK w/ Puro mGFP w/ Puro
  $1,744.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Tagged ORF Clone
Target Symbol PDGF Receptor beta
Synonyms CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PENTT
Vector pLenti-C-mGFP-P2A-Puro
E. coli Selection Chloramphenicol (34 ug/mL)
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC206377).
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_002609
ORF Size 3318 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_002609.3
RefSeq Size 5718 bp
RefSeq ORF 3321 bp
Locus ID 5159
UniProt ID P09619
Cytogenetics 5q32
Domains ig, IG, IGc2, pkinase, S_TKc, TyrKc
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton
MW 123.8 kDa
Summary The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. provided by RefSeq, Aug 2017
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"NM_002609" in other vectors (7)
SKU Description Size Price
RC206377 PDGFRB (Myc-DDK-tagged)-Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) 10 ug
$1,444.00
RC206377L1 Lenti ORF clone of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB), Myc-DDK-tagged 10 ug
$1,744.00
RC206377L2 Lenti ORF clone of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB), mGFP tagged 10 ug
$1,744.00
RC206377L3 Lenti ORF clone of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB), Myc-DDK-tagged 10 ug
$1,744.00
RC600017 PDGFRB (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens platelet-derived growth factor receptor, beta polypeptide, Signal peptide (1-32) plus EC domain (33-532) 10 ug
$743.00
RG206377 PDGFRB (tGFP-tagged) - Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) 10 ug
$789.00 $1,644.00
SC309979 PDGFRB (untagged)-Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) 10 ug
$1,445.00

Plasmid Map for RC206377L4

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file-download TXT (FASTA format)

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Cloning scheme for RC206377L4
Circular map for RC206377L4

file-alt Citations

Discovery and Evaluation of Biomarkers for Triple-Negative Breast Cancer Subtypes Uncovers Patient Stratification and Targeted Therapeutic Strategies
Ortega-Álvarez, Tébar-García, Casado-Peláez et al
Cancer Res (2026)
AI Summary: OriGene’s PDGFRB Human Tagged Lenti ORF Clone (RC206377L4) was used to generate lentiviral particles for PDGFRB overexpression, enabling functional studies that contributed to biomarker validation and therapeutic evaluation in triple-negative breast cancer models.
Snippet: After 24 h at 37 °C, transfected cells 256 were plated in 96-well dishes for cellular subcloning. For PDGFRB overexpression, lentiviral particles were 257 generated using the PDGFRB Human Tagged Lenti ORF Clone (RC206377L4, Origene) plasmid and used to 258 transduce target cells
Showing 1-1 of 1 papers.
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